Journal of Carcinogenesis & Mutagenesis

Shashi Singh Pawar

Publications

• Case Report
  Paraneoplastic Leukemoid Reaction in a Case of Carcinoma Gall Bladder: A Rare Scenario
  Author(s): Jeetendar Paryani, Sameer Gupta, Arun Chaturvedi, Vijay Kumar, Naseem Akhtar, Parijat Suryavanshi and Shashi Singh PawarJeetendar Paryani, Sameer Gupta, Arun Chaturvedi, Vijay Kumar, Naseem Akhtar, Parijat Suryavanshi and Shashi Singh Pawar
  
  Paraneoplastic Leukemoid reaction may be defined as elevated WBC counts in association of solid malignancy when other causes like infection and hematological malignancies have been ruled out. The exact mechanism has not been fully elucidated. It is likely that various cytokines produced irregularly by the tumor cells, including granulocyte colony-stimulating factor (G-CSF), may underlie the pathogenesis. We here describe a case report of 68-year-old man with locally advanced gall bladder presenting with extremely elevated WBC count. Infection, leukemia, bone marrow involvement were ruled out. Patient underwent surgery and after resection counts normalized. Patient had recurrence few months later which was accompanied by raised TLC. There are many studies associating this rare phenomenon with lung urothelial melanomas and other malignancies but not with gall bladder.. View More»
  DOI: 10.4172/2157-2518.1000332

  Abstract PDF