Journal of Biomolecular Research & Therapeutics

Samuel T Melek

Publications

• Research Article
  Biological Evidences of Hepatocellular Carcinoma Treatment with 1,3,4-oxadiazole-2-thiol as Anticancer Agent
  Author(s): Mohamed S Gabry, Galal H Elgemeie, Nahed S Basseli, Samuel T Melek, Saadia E Hafez, Omar A Farid and Shimaa S AbdelhadyMohamed S Gabry, Galal H Elgemeie, Nahed S Basseli, Samuel T Melek, Saadia E Hafez, Omar A Farid and Shimaa S Abdelhady
  
  Purpose: In recent years, identification of novel potent, selective, and less toxic anticancer agents remains one of the most pressing health problems. This research aimed to in vivo illustration of 1,3,4-oxadiazole-2-thiol (OXD-T) anticancer activities as a discovery of the treatment of Hepatocellular Carcinoma (HCC) of Albino rats. Methods: Hepatocellular carcinoma was induced by 3,3’-Diamino benzidine for three months, three times per week. The post treatment of HCC induced rats was carried out with OXD-T therapeutic (300 mg/kg. b.wt.) and half therapeutic doses (150 mg/kg b.wt.) of administration. Biochemical parameters and comet assay were assessed to evaluate the efficiency of OXD-T treatment on the HCC induced animal. Results: The administration of 1,3,4-oxadiazole-2-thiol (OXD-T) with therapeutic dose.. View More»
  DOI: 10.4172/2167-7956.1000153

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