Journal of Carcinogenesis & Mutagenesis

Robert Vander Broek

Publications

• Review Article
  Signaling Networks of Activated Oncogenic and Altered Tumor Suppressor Genes in Head and Neck Cancer
  Author(s): Bin Yan, Robert Vander Broek, Anthony D Saleh, Arpita Mehta, Carter Van Waes and Zhong ChenBin Yan, Robert Vander Broek, Anthony D Saleh, Arpita Mehta, Carter Van Waes and Zhong Chen
  
  Head and neck squamous cell carcinoma (HNSCC) arises from the upper aerodigestive tract and is the six most common cancers worldwide. HNSCC is associated with high morbidity and mortality, as standard surgery, radiation, and chemotherapy can cause significant disfigurement and only provide 5-year survival rates of ~50- 60%. The heterogeneity of HNSCC subsets with different potentials for recurrence and metastasis challenges the traditional pathological classification system, thereby increasing demand for the development of new diagnostic, prognostic, and therapeutic tools based on global molecular signatures of HNSCC. Historically, using classical biological techniques, it has been extremely difficult and time-consuming to survey hundreds or thousands of genes in a given disease. However, the development of high throughput technologies and high-powered computation throughout the last .. View More»
  DOI: 10.4172/2157-2518.S7-004

  Abstract PDF