Journal of Carcinogenesis & Mutagenesis

Richard L Carpenter

Publications

• Review Article
  Regulation of Apoptosis by HER2 in Breast Cancer
  Author(s): Richard L Carpenter and Hui-Wen LoRichard L Carpenter and Hui-Wen Lo
  
  HER2 is a trans-membrane receptor tyrosine kinase that activates multiple growth-promoting signaling pathways including PI3K-AKT and Ras-MAPK. Dysregulation of HER2 is a frequent occurrence in breast cancer that is associated with poor patient outcomes. A primary function of HER2 is suppressing apoptosis to enhance cell survival giving rise to uncontrolled proliferation and tumor growth. There has been much investigation into the mechanisms by which apoptosis is suppressed by HER2 in hopes of finding clinical targets for HER2-positive breast cancers as these cancers often become resistant to therapies that directly target HER2. Several apoptotic mechanisms have been shown to be deregulated in HER2-overexpressing cells with examples in both the intrinsic and extrinsic apoptotic pathways. HER2-mediated activation of PI3K-AKT signaling is required for many of the mechanisms HER2 uses to .. View More»
  DOI: 10.4172/2157-2518.S7-003

  Abstract PDF