Journal of Carcinogenesis & Mutagenesis

Rasika Priyadharshani Ekanayaka

Publications

• Review Article
  Oral Submucous Fibrosis: Review on Mechanisms of Pathogenesis and Malignant Transformation
  Author(s): Rasika Priyadharshani Ekanayaka and Wanninayake Mudiyanselage TilakaratneRasika Priyadharshani Ekanayaka and Wanninayake Mudiyanselage Tilakaratne
  
  Studies focusing on epidemiology, histopathology and molecular biology/pathology on various aspects of oral submucous fibrosis (OSF), especially in the last decade have helped to understand the pathogenesis to a larger extent. In addition research in some aspects of carcinogenesis in the background of fibrosis has also advanced significantly in the recent past allowing us to understand the mechanisms involved in malignant transformation of the most prevalent oral potentially malignant disorder in South Asia. It has been shown that pathogenesis of OSF is directly related to arecoline present in arecanut and most of the alterations in various pathways and molecules leading to accumulation of collagen are mediated as a result of arecoline. Reduction of Matrix metalloproteinases (MMPs) and increased secretion of Tissue inhibitors of matrix metalloproteinases (TIMPs) play the most signific.. View More»
  DOI: 10.4172/2157-2518.S5-002

  Abstract PDF