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Rani S

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  • Case Report
    Paroxysmal Cold Hemoglobinuria: Role of Hospital Transfusion Medicine and Immunohematology Department in the Diagnosis
    Author(s): Sood R, Suman N, Rani S and Kumar VSood R, Suman N, Rani S and Kumar V

    Background: Paroxysmal cold hemoglobinuria (PCH), an autoimmune hemolytic anaemia caused due to polyclonal IgG anti-P autoantibody binding to red blood cell surface antigens and is characterized by hemoglobinuria, typically after exposure to cold temperatures. Case Presentation: An 84-year-old female patient started developing breathing difficulty off and on with generalised weakness and loss of appetite. There was continuous fall in hemoglobin and continuous evidence of intravascular hemolysis since last 15 days. After ruling out many common diagnosis, Donath – Landsteiner Test was done which showed Immunoglobulin G, IgG, antibodies, appearing at 4ºC and hemolysing at 37ºC in the presence of complement. Peripheral smear showed anisopoikilocytosis and spherocytosis. Reti.. View More»

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