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Rajkumar
Rajkumar
India
Publications
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Research Article
Assessment of Serum and Salivary Progranulin Levels in Oral Submucous Fibrosis
Author(s): Swarnalakshmi R, Ramya R, Priyadharshini N, Preethi L, Rajashree P and RajkumarSwarnalakshmi R, Ramya R, Priyadharshini N, Preethi L, Rajashree P and Rajkumar
Background: Oral submucous fibrosis is a chronic inflammatory condition and a common potentially malignant oral disorder. It has been postulated that inflammation and cancer share a common link by activation of common transcription factors which enhances gene expression involved in the regulation and production of inflammatory mediators and also in the regulation of survival and proliferation of cancer cells. Inflammation has been added as one of the hallmarks in cancer development. Progranulin or proepithelin is a high molecular weight secreted mitogen, it has been recently introduced as a novel marker for chronic inflammatory response. The functions of progranulin is multifaceted; progranulin levels have yet been unexplored in the context of submucous fibrosis as well as oral cancer. Aim: To assess Serum and Salivary Progranulin Levels i.. View More»
DOI: 10.4172/2157-2518.1000311