Biochemistry & Analytical Biochemistry

Preetam Nath

Publications

• Commentary
  Serum Transaminases: Quo Vadis
  Author(s): Preetam Nath and Shivaram Prasad SinghPreetam Nath and Shivaram Prasad Singh
  
  Serum transaminases (also called aminotransferases) are basically enzymes in the human body which help in catalyzing reactions involving transfer of the α-amino groups. Alanine transaminase (ALT) helps in conversion of alanine into pyruvate and Aspartate transaminase (AST) helps in formation of α-ketoglutarate from aspartate . Both AST and ALT are sensitive markers of acute hepatocellular injury and are routinely used to identify liver disease since 1955. Both are readily available, inexpensive, and routinely assayed in clinical practice. AST which was formerly known as serum glutamic oxaloacetic transaminase (SGOT), is found in both cytosol and mitochondria in several organs such as the liver, cardiac muscle, skeletal muscle, kidney, brain, pancreas, lung, leukocytes, and erythrocytes but the concentration is highest in the hepatic parenchyma. On the contrary, ALT (former.. View More»
  DOI: 10.4172/2161-1009.1000260

  Abstract PDF