Journal of Carcinogenesis & Mutagenesis

Paula L Hyland

Publications

• Research Article
  Constitutive Mitochondrial DNA Copy Number in Peripheral Blood of Melanoma Families with and without CDKN2A Mutations
  Author(s): Paula L Hyland, Ruth M Pfeiffer, Melissa Rotunno, Jonathan N Hofmann, Chin-San Liu, Wen-Ling Cheng, Jeff Yuenger, Qing Lan, Margaret A Tucker, Alisa M Goldstein and Xiaohong R YangPaula L Hyland, Ruth M Pfeiffer, Melissa Rotunno, Jonathan N Hofmann, Chin-San Liu, Wen-Ling Cheng, Jeff Yuenger, Qing Lan, Margaret A Tucker, Alisa M Goldstein and Xiaohong R Yang
  
  Quantitative changes in mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between constitutive mtDNA copy number in blood and the risk of familial cutaneous malignant melanoma (CMM) has not been reported. We measured mtDNA copy number using quantitative PCR in blood-derived DNA from 136 CMM cases and 302 controls in 53 melanoma-prone families (23 segregating CDKN2A germline mutations). MtDNA copy number did not vary by age, sex, pigmentation characteristics, or CMM status. However, germline CDKN2A mutation carriers had significantly higher mean mtDNA copy number compared to non-carriers, particularly among CMM cases (geometric mean mtDNA copy number of 144 and 111 for carrier versus non-carrier, respectively; P= 0.02). When adjusting for age, sex, and familial correlation, having increasing mtDNA copy.. View More»
  DOI: 10.4172/2157-2518.S4-006

  Abstract PDF