Journal of Pharmacogenomics & Pharmacoproteomics

Paul A Gurbel

Biography

Gurbel earned his medical degree at the University of Maryland School of Medicine and completed an internship and residency in internal medicine at Duke University Medical Center in Durham, N.C. He then completed his fellowship in pulmonary and critical care at Johns Hopkins University, followed by fellowships in cardiovascular disease and interventional cardiology as well as a chief residency in internal medicine at Duke.

Research Interest

Research interest in the area of coronary thrombosis because that event is associated with poor outcomes in patients undergoing PCI and it’s the lethal pathophysiologic event. Unlike restenosis, which can also be lethal, stent thrombosis is usually the most critical event. It’s the No. 1 thing I focus on in my lab. The whole process of stent thrombosis and how potentially deadly it is stimulated my lab to study it. This, in turn, got us to begin looking at the pharmacodynamic effect of the different drugs to try to understand how effective one drug is vs. another in blocking the physiology of the platelet, which is believed to be one of the major players in the genesis of thrombotic events after stenting.