Pharmaceutica Analytica Acta

Nilesh Jain

Publications

• Research Article
  Mixed Hydrotropy Solubilization Approach for Quantitative Estimation of Eprosartan Mesylate and Hydrochlorthiazide by UV Spectrophotometer
  Author(s): Ruchi Jain, Vinod Sahu, Nilesh Jain and Surendra JainRuchi Jain, Vinod Sahu, Nilesh Jain and Surendra Jain
  
  Two simple, accurate, novel, safe and precise methods were developed for the simultaneous estimation of poorly water-soluble drugs Eprosartan Mesylate and Hydrochlorthiazide in tablet dosage form using 2M Sodium acetate and 8M Urea solution (50:50% W/V) as a mixed hydrotropic solution. Eprosartan Mesylate and Hydrochlorthiazide show maximum absorbances at 267.5 and 271.5 nm respectively. Sodium acetate and Urea solution did not show any absorbance above 240 nm and thus no interference in the estimation of drugs was seen. Eprosartan Mesylate and Hydrochlorthiazide follows the Beer’s law in the concentration range of 15-75 and 5-25 μg/ml (r 2 = 0.9994 and 0.9996). Method-A employs a simultaneous equation method using 267.5 and 271.5 nm as two analytical wavelengths, Method-B, an absorption ratio method, uses 271.5 and 277 nm as two analytical.. View More»
  DOI: 10.4172/2153-2435.1000135

  Abstract PDF