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Neeti Nema
Neeti Nema
India
Publications
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Research Article
Drug Nano-particle: A Release Kinetics
Author(s): Roli Jain, Sandeep Kumar Sukla, Neeti Nema and Archna PandayRoli Jain, Sandeep Kumar Sukla, Neeti Nema and Archna Panday
Depression is estimated to affect nearly 340 million people worldwide and 18 million people in the US at any given time making it the third most costly and disabling illness in the US. Duloxetine hydrochloride is one of the main antidepressant used as a selective serotonin and nor epinephrine reuptake inhibitor (SSNRI) for oral administration. As it works on central nervous system (CNS), drug should be more available to the cells. To increase the efficacy and solubility drug can be formulated with polymers using nano particle as a drug carriers. In this work we propose and analyzed different approaches to study measuring the size of nano particle and effect of these nano particles on the in vitro kinetics dissolution behavior. The drug obeyed the beers law over the range of 5-50 μg/ml at λmax 230 nm. Drug with PEG 4000 in 6... View More»
DOI: 10.4172/2157-7439.1000317