Journal of Pharmacogenomics & Pharmacoproteomics

Narumol Trachu

Publications

• Research Article
  Pharmacogenetic Study of 5-Fluorouracil-Related Severe Toxicity in Thai Cancer Patients: A Novel SNP Detection
  Author(s): Ekaphop Sirachainan, Thanyanan Reungwetwattana, Yupin Wisetpanit, Ravat Panvichian, Thitiya Sirisinha, Touch Ativitavas, Vorachai Ratanatharathorn, Narumol Trachu and Chonlaphat SukasemEkaphop Sirachainan, Thanyanan Reungwetwattana, Yupin Wisetpanit, Ravat Panvichian, Thitiya Sirisinha, Touch Ativitavas, Vorachai Ratanatharathorn, Narumol Trachu and Chonlaphat Sukasem
  
  Objective: The objective of this study is to determine the extent of (DPYD) Dihydropyrimidine Dehydrogenase Gene] polymorphisms of Thai cancer patients who received 5-FU based chemotherapy regimens. Methods: The study was conducted a pharmacogenetic analysis to determine the polymorphisms of DPYD gene in 116. Thai cancer patients. 76 patients developed severe (grade 3-4) toxicities after receiving the first or second cycle of 5-FU based chemotherapy. The other subject group consisted of 40 patients without severe toxicity. The DNA sequencing of every amplicon was done to identify 11 mutations as reported in Asian population. The actual change of absolute neutrophil count (ANC), hematocrit, platelet and percentage of neutrophil were compared. Results: We detected 13 SNPs of which 6 SNPs were found in exons; 967G>A, 1011A>T, 1236G>A, 1774C>T, 1896T>C and 162.. View More»
  DOI: 10.4172/2153-0645.1000112

  Abstract PDF