Pharmaceutica Analytica Acta

Nagib Qarah AS

Publications

• Research Article
  Sensitive and Selective Extraction-Free Spectrophotometric Assay of Chloroquine Phosphate in Pharmaceuticals Based on Ion-Pair Reaction with Bromocresol Green and Bromocresol Purple
  Author(s): Nagib Qarah AS, Basavaiah K and Swamy NNagib Qarah AS, Basavaiah K and Swamy N
  
  Chloroquine Phosphate (CQP) is an antimalarial agent extensively used in the treatment of malaria. Two spectrophotometric methods, which are rapid, simple, selective and sensitive, are presented for the determination of CQP in bulk and dosage forms using two sulphonphthalein dyes: Bromocresol Green (BCG method) and Bromocresol Purple (BCP method). The methods are based on the formation of chloroform-soluble ion-pairs, when CQP is reacted with either dye, suitable for measurement at 420 nm in both the methods. The effects of reaction time, dye concentration and reaction medium were carefully studied and optimized. Under the optimum reaction conditions, Beer's law is obeyed overconcentration ranges 1-20 and 0.5-12 μg mL-1 CQP (base) for BCG method and BCP method respectively, with corresponding molar absorptivity values of 1.79 × 104 and 3.09 × 104 L mol-1 cm-1. The calcu.. View More»
  DOI: 10.4172/2153-2435.1000539

  Abstract PDF