Pharmaceutica Analytica Acta

Nagarjun R

Publications

• Research Article
  Fabrication of Surgical Sutures Coated with Curcumin Loaded Gold Nanoparticles
  Author(s): Sunitha S, Adinarayana K, Pankaj T, Sravanthi Reddy P, Sonia G, Nagarjun R, Veerabhadra Swamy C and Sujatha DSunitha S, Adinarayana K, Pankaj T, Sravanthi Reddy P, Sonia G, Nagarjun R, Veerabhadra Swamy C and Sujatha D
  
  Sutures are biomaterials regarded as a major cause of Surgical Site Infections (SSIs). Present work aims at a novel strategy to reduce nosocomial infections by coating sutures with antimicrobial drugs. Gold Nanoparticles (GNPs) coated with antimicrobial drugs are well known for their antimicrobial activity. Hence, synthesis of gold nanoparticles by chemical reduction method followed by preparation of curcumin pegylated GNPs (CPGNPs) were carried out. The formation of the gold nanoparticles, thiolated gold nanoparticles (PGNPs) and CPGNPs was characterized by UV-Vis absorption spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) techniques. The average particle size and polydispersity index of drug conjugated gold NPs were found to be 147.8 nm ± 2.03 nm and 0.286 respectively. The plain sutures (purchased from local market) were co.. View More»
  DOI: 10.4172/2153-2435.1000529

  Abstract PDF