Journal of Pharmacogenomics & Pharmacoproteomics

Nabila Vallés-Ortiz

Publications

• Research Article
  Frequencies of Functional Polymorphisms in Three Pharmacokinetic Genes of Clinical Interest within the Admixed Puerto Rican Population
  Author(s): Carmelo Orengo-Mercado, Bianca Nieves, Lizbeth López, Nabila Vallés-Ortiz, Jessicca Y. Renta, Pedro J. Santiago-Borrero, Carmen L. Cadilla and Jorge DucongeCarmelo Orengo-Mercado, Bianca Nieves, Lizbeth López, Nabila Vallés-Ortiz, Jessicca Y. Renta, Pedro J. Santiago-Borrero, Carmen L. Cadilla and Jorge Duconge
  
   Objective: This cross-sectional study was aimed at determining the allele frequencies for the CYP2C19*2, CYP2C19*3, CYP2D6*10 and PON1 (rs662) polymorphisms in the Puerto Rican population. The CYP2C19, CYP2D6 and PON1 genes are known to be associated with functional changes in drug metabolism and activation. Individuals carrying the aforementioned polymorphisms are at a higher risk of suffering from drug-induced adverse events and/ or unresponsiveness from a variety of drugs that includes antidepressants, atypical antipsychotics and antiplatelet compounds. Information on the frequency of these polymorphisms is more commonly found on homogeneous populations, but is scarce in highly heterogeneous populations like Hispanics, as in the case of Puerto Ricans. Method: Genotyping was carried out in 100 genomic DNA samples from dried blood spots supplied by the Puerto Ric.. View More»
  DOI: 10.4172/2153-0645.1000113

  Abstract PDF