Mukesh R Patel

  • Research Article
    Enhanced Solubility and Dissolution Rate of Aceclofenac by Using Spray Drying Techniques
    Author(s): Sahilhusen I Jethara and Mukesh R PatelSahilhusen I Jethara and Mukesh R Patel

    The present study deals with improvement in aqueous solubility of aceclofenac using HPMC K-15M, PVP-K30 and Eudragit RS-100 in varying ratio by spray-drying at the optimized condition. The samples of solid dispersion were subjected to Fourier transform infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction morphology (PXRD), scanning electron microscopy (SEM), in vitro drug release and stability studies. A decrease in the melting enthalpy in DSC indicates conversion of crystalline to an amorphous state. The results were supported by PXRD, FTIR and SEM data revealed a characteristic decrease in crystallinity. The dissolution studies demonstrated a marked increase in the dissolution rate in comparison with pure drug. The considerable improvement in the dissolution rate of aceclofenac from spray drying, decreased drug crystallinity, altered surfa.. Read More»
    DOI: 10.4172/2375-4516.1000140

    Abstract PDF