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Mukesh R. Patel
Mukesh R. Patel
India
Publications
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Research Article
Development and Evaluation of Bilayer Tablet of Metoclopramide HCl and Aceclofenac
Author(s): Sahilhusen I. Jethara and Mukesh R. PatelSahilhusen I. Jethara and Mukesh R. Patel
Bilayer tablets are basically used to administer a dosage form with dual release effect or to formulate two incompatible drugs. The main objective of the present research work was to prepare bilayer tablet of Metoclopramide hydrochloride (MTH) and Aceclofenac (ASF) for separate layers to avoid the degradation of the drug, with the desired release pattern and thus to maximize the efficacy of both drugs in combination for the effective treatment of migraine. MTH and ACF were formulated as immediate and conventional release layer respectively. ASF was formulated as conventional release layer using PVP K-30 and MCC as binder and disintegrants respectively. MTH was formulated as immediate release layer by using various disintegrants like Sodium starch glycolate (SSG), Cross carmellose sodium (CCS) and Pre-gelatinized starch (PGS). Mixture design technique was used to find out the optimized.. View More»
DOI: 10.4172/2375-4516.1000138