Pharmaceutica Analytica Acta

Mohamed Alaama

Publications

• Conference Proceeding
  Anticancer Effects of Medical Malaysian Leech Saliva Extract (LSE)
  Author(s): Ahmed Merzouk, Abbas Mohammad Ghawi, Abdualrahman M. Abdualkader, Abubakar Danjuma Abdullahi and Mohamed AlaamaAhmed Merzouk, Abbas Mohammad Ghawi, Abdualrahman M. Abdualkader, Abubakar Danjuma Abdullahi and Mohamed Alaama
  
  Leech saliva contains biologically active compounds that are mainly proteins & peptides. Small cell lung cancer (SCLC) is a form of cell lung carcinoma. In this study a modified and smooth extraction method of saliva was used without leech scarification. Trying to find out the biological activity of medical Malaysian Leech Saliva Extract as cytotoxic in vitro, the SW 1271 cell line was grown and maintained in Leibovitz’ s L-15 medium supplemented with 10% foetal bovine serum at 37° C in normal atmospheric air. Serial dilutions of LSE were added to the cell line SW 1271 media for testing the cytotoxic activities.Result revealed that the LSE has a cytotoxic activity against small cell lung cancer(SW 1271 cell line) with IC50 of 119.844 µg/ml compared with IC50 values of two reference standard drugs Irinotecan (5.81 µg/ml) and Carboplatin(18.754 µg/ml). In.. View More»
  DOI: 10.4172/2153-2435.S15-001

  Abstract PDF