Journal of Carcinogenesis & Mutagenesis

Miklós Kasler

Publications

• Research Article
  The EGFR and KRAS Mutation Status and Correlations with the Prevalence of Bone Metastases - The Results of Three Year Retrospective Analysis
  Author(s): Nora Bittner, Zoltan Baliko, Veronika Sarosi, Terezia Laszlo, Zoltan Szentirmay, Erika Tóth, Lajos Geczi and Miklós KaslerNora Bittner, Zoltan Baliko, Veronika Sarosi, Terezia Laszlo, Zoltan Szentirmay, Erika Tóth, Lajos Geczi and Miklós Kasler
  
  Lung cancer is the leading cause of cancer related mortality all over the world. The development of molecular pathology methods has become increasingly important in the prediction of chemotherapy sensitivity and mutation analysis to identify driver mutations as important targets of new therapeutic agents. These agents give an opportunity to provide a new standard of care. Therefore testing EGFR, KRAS mutations and ALK rearrangements in patients with advanced lung adenocarcinoma should be incorporated into routine clinical practice. Bone is the most frequent type of distant metastases in case of Non-Small Cell Lung Cancer (NSCLC). During the disease this is developing 30-40%. Because of the short survival (6 months) the treatment possibilities were not in the aim of scope. After the changes of treatment guidelines – first the platinum based chemotherapy, later the step of EGFR TK.. View More»
  DOI: 10.4172/2157-2518.1000184

  Abstract PDF