Journal of Nanomedicine & Nanotechnology

Meser M Ali

Biography

 Meser M. Ali received his Ph.D. degree in Organometallic Chemistry from the University of Mie in Japan in 1999.  He is a Senior Staff Investigator in the Department of Neurology at Henry Ford Hospital, Detroit, Michigan, USA.   His research program focuses on the development of small-sized nanoparticles that can cross tumor blood brain barrier for potential applications of brain tumor imaging and therapy

Research Interest

  My research interest is in the discipline of nanomedicine and drug delivery with noninvasive molecular imaging. Nanomedicine, carrying therapeutic payloads and delivered within close proximity of the tumor, can be designed to play a significant role in increasing treatment effectiveness while decreasing severity of side effects. Specifically, my research work focuses in developing small nano-sized paramagnetic nanoparticles that can cross tumor blood brain barrier and target primary glioblastoma multiform (GBM) selectively. My work resulted in the development of a series of new dendrimer-based multifunctional nanoparticles that are detected by standard MR relativity methods or new MRI methods based on Paramagnetic Chemical Exchange Saturation Transfer (PARACEST). My developments of small nano-sized molecular imaging agents that target GBM selectively. Therefore, primary GBM tumor selective drug delivery and imaging can be accomplished by using these dendrimer-based nanoparticles that possess long blood half-lives. We have reformulated promising anti-cancer drugs that failed to reach clinical trials, or failed in clinical trials due to toxicity or poor bioavailability. These reformulations have reproduced usable, safe therapies using nanoparticles. I have also used state-of-the-art MRI methods to study tumor progression and the early responses to chemotherapies in pre-clinical animal models.