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Mei Xiao
Mei Xiao
China
Publications
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Review Article
Effect of Antimicrobial Triclosan on Reproductive System of Male Rat
Author(s): Fahar Ibtisham, Aamir Nawab, Yi Zhao, Guanghui Li, Mei Xiao and Lilong AnFahar Ibtisham, Aamir Nawab, Yi Zhao, Guanghui Li, Mei Xiao and Lilong An
Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol: TCS) is a synthetic, broad-spectrum antibacterial agent used in broad range of household and personal care products including hand soap, toothpaste, and deodorants. Recently, concerns have been raised over TCS?s potential for endocrine and reproductive disruption. This review contains the information about deleterious toxic effects of TCS on reproductive system of male rat and the possible mechanism. The literature findings showed that TCS deadly affects the reproductive profile of male rats. According to literature TCS depress the testicular function of male rat including spermatogenesis and steroidogenesis by decreasing the androgen production. 3-hydroxysteroid dehydrogenase (3?-HSD) and 17?-hydroxysteroid dehydrogenase (17?- HSD) are two critical enzymes in the steroidogenesis pathway, while according to findings TCS treated rats had .. View More»
DOI: 10.4172/2153-2435.1000516