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Malzev VN
Malzev VN
Urologische Praxis,
Bahnhofstr. 1, 30159 Hanover
Germany
Publications
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Review Article
Hallmarks of Cancer: Interpretation as Carcinogenic Hypercycle
Author(s): Malzev VN Malzev VN
The mechanism that is the base of all hallmarks is the genetic instability as a result of continuously occurring mutations and egipenomic DNA modifications in a cancer cell. It cannot be explained by simple accumulation of genome mutations. Continuous mutation and epigenetic modification are only possible as a result of continuous impact of a mutagenic factor. Cyclic DNA replication reaction and/or RNA of mobile genetic elements are this mutagenic agent. These elements are generated as a result of inner-cell chaos of molecular biological processes that is caused by the impact of a cancerogenic factor. After their generation, they can create a hypercyclic link to the cell DNA replication cycle and hence cause mutations and epigenetic modifications in this cell. A new type of selforganisation of inner-cell processes and structures named primary cancerogenic hypercycle is generated. Thes.. View More»
DOI: 10.4172/2517-2518.1000252