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Mahjabeen I
Mahjabeen I
Pakistan
Publications
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Research Article
Association of Promoter Polymorphisms in Xrcc2 Gene Involved in DNA Double Strand Break Repair and Increased Susceptibility to Thyroid Cancer Risk in Pakistani Population
Author(s): Sarwar R, Bashir K, Saeed S, Mahjabeen I and Kayani MASarwar R, Bashir K, Saeed S, Mahjabeen I and Kayani MA
Introduction: The incidence of thyroid cancer (TC) has rapidly increased globally in recent decades. It is the most frequent endocrine malignancy which is fifth most common cancer in females. Double strand break repair (DSBR) pathway gene, X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2 (XRCC2) has high rate of polymorphisms and may cause individual’s susceptibility towards carcinogenesis including thyroid cancer. Objective: Main objective of present study is to find the association of hotspot promotor polymorphisms in XRCC2 gene with thyroid cancer risk. Methods: In this study, we performed genetic association studies in 856 individuals (456 cases and 400 controls) for three promoter region SNPs of XRCC2 gene i.e., G4234C (rs3218384), G4088T (rs3218373) and G3063A (rs2040639). Genotyping was performed by amplification refractory mutation s.. View More»
DOI: 10.4172/2157-2518.1000265