Pharmaceutica Analytica Acta

Mahadik KR

Publications

• Research Article
  Role of Piperine as an Effective Bioenhancer in Drug Absorption
  Author(s): Mhaske DB, Sreedharan S and Mahadik KRMhaske DB, Sreedharan S and Mahadik KR
  
  Bioenhancers can be defined as chemical entities, which when mixed with drugs promote and augment their bioavailability without showing any synergistic effect with the drug. The factors like toxicity, cost, poor bioavailability and long term administration of drugs give rise to the need of bioenhancers which help overcome most of these problems. Piper species produce a pungent alkaloid named Piperine or 1-peperoyl piperidine. Piperine increases permeability at the site of absorption by modulating lipid environment and membrane dynamics. Piperine has a molecular structure that is suitable for enzyme inhibition. It augments the bioavailability of several drugs like carbamazepine, curcumin, ciprofloxacin, ampicillin, metronidazole, oxytetracycline and many others by inhibiting various metabolizing enzymes. Thus piperine, being an efficacious inhibitor of drug metabolism is a powerful enh.. View More»
  DOI: 10.4172/2153-2435.1000591

  Abstract PDF