Journal of Nanomedicine & Nanotechnology

Lothar Koch

Publications

• Research Article
  Functional Titanium Lotus-Topography Promotes the Osteoinduction of Human Adipose-Derived Stem Cells In Vitro
  Author(s): Andrea Deiwick, Elena Fadeeva, Lothar Koch, Reiner Gebauer, Boris Chichkov and Sabrina Schlie-WolterAndrea Deiwick, Elena Fadeeva, Lothar Koch, Reiner Gebauer, Boris Chichkov and Sabrina Schlie-Wolter
  
  For orthopedic applications, biomaterials are required which (a) enable bone cell anchorage, (b) stimulate osteogenic differentiation, (c) reduce the risk of infections and immune rejection, and (d) have appropriate mechanical properties similar to native bone. To enhance the biological performance of titanium, surface structuring by ultrashortpulse laser ablation was tested. This nanotechnology enables high precision, reduced head-affected zones, and small amount of debris around the ablated area. Various surface features in almost all solid materials can be fabricated. In order to mimic the complex architecture of natural bone, a lotus-topography was generated. Recently, we demonstrated that lotus-features reduce immune rejection and minimize the risk of infections in vitro. Using human adipose-derived stem cells (hASC) we show that significantly more cells were adherent on .. View More»
  DOI: 10.4172/2157-7439.1000239

  Abstract PDF