Journal of Nanomedicine & Nanotechnology

Lionel Marcon

Publications

• Research Article
  Synthesis of Highly-loaded Holmium-165 Siloxane Particles for Brachytherapy of Brain Cancer and Injectability Evaluation in Healthy Pig
  Author(s): Lionel Marcon, Helene Gehan, Khoshnevis M, Marmuse L, Carozzo C, Louis C, Ponce F and Tillement OLionel Marcon, Helene Gehan, Khoshnevis M, Marmuse L, Carozzo C, Louis C, Ponce F and Tillement O
  
  Glioblastoma is the most invasive type of glial tumors, rapidly growing and commonly spreading into nearby brain tissue. Internal radiotherapy, also called brachytherapy, is an advanced cancer treatment where radioactive seeds are placed in or near the tumor itself, giving a high radiation dose to the tumor while reducing the radiation exposure in the surrounding healthy tissues. Among the available radioactive materials, 166Ho emits high-energy β radiation required for tumor destruction and low-energy γ radiation which can be used for quantitative SPECT imaging. In addition, Ho is a highly paramagnetic element and can therefore be visualized by MRI. In this context, we synthesized 400 nm particles via a sol-gel process in acidic conditions using holmium (III) oxide Ho2O3 as a nanostructured precursor. The objective was to design particles with a high 1.. View More»
  DOI: 10.4172/2157-7439.1000460

  Abstract PDF