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Lin Li
Lin Li
School of Mechanical and Aerospace Engineering,
50 Nanyang Avenue, Singapore 639798
Singapore
Publications
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Research Article
Fabrication of Nanoparticles of Silymarin, Hesperetin and Glibenclamide by Evaporative Precipitation of Nanosuspension for Fast Dissolution
Author(s): Kakran M, Sahoo GN and Lin LiKakran M, Sahoo GN and Lin Li
Evaporative precipitation of nanosuspension (EPN) was used to prepare nanoparticles of poorly water soluble drugs, namely silymarin (SLM), hesperetin (HSP) and glibenclamide (GLB), with the aim of improving their rate of dissolution. The original drugs and EPN prepared drug nanoparticles were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and dissolution tester. The particle sizes were found to be influenced by the drug concentration and the solvent to antisolvent ratio. The smallest average particle sizes obtained were 350 nm for SLM, 450 nm for HSP and 120 nm for GLB. The DSC study suggested that the crystallinity of EPN prepared drug nanoparticles was lower than the original drug. The dissolution rate of EPN prepared drug nanoparticles markedly increased as compared to original drug. The dissolution rate was increased by up to 95% for SLM .. View More»
DOI: 10.4172/2153-2435.1000326