Pharmaceutica Analytica Acta

Joost PH Drenth

Publications

• Research Article
  Urinary Excretion Levels of MMX-Mesalazine as a Tool to Assess Non-Adherence
  Author(s): Tessa EH Romkens, Jody Salomon, Wilbert HM Peters, David M Burger, Frank Hoentjen and Joost PH DrenthTessa EH Romkens, Jody Salomon, Wilbert HM Peters, David M Burger, Frank Hoentjen and Joost PH Drenth
  
  Objective: 5-Amino salicylicacid (5-ASA) is the cornerstone of ulcerative colitis treatment, with (assessment of) non-adherence as a challenge. Multi-matrix release (MMX)-mesalazine has the advantage of once-daily (OD) dosing. Primarily we assessed urinary (NAc-) 5-ASA excretion, as measured by High-Performance Liquid Chromatography (HPLC), in order to monitor nonadherence, in healthy volunteers taking MMX-mesalazine. Secondly, we established urinary (NAc-)5-ASA cut-off levels for (partial) nonadherence. Method: We studied 25 healthy adult volunteers who used MMX-mesalazine 2400 mg OD (days 1-4), followed by 1200 mg twice daily (BID) (days 8-11), separated by a drug-free interval of 3 days. Daily morning urine spot samples were collected. The cut-off level for adherence was set at the lowest steady state (NAc-)5-ASA urinary concentration level. Results: Stability of urinary 5-ASA and .. View More»
  DOI: 10.4172/2153-2435.1000443

  Abstract PDF