Journal of Pharmacogenomics & Pharmacoproteomics

John P. Overington

Biography

John studied Chemistry at the University of Bath, from where he graduated in 1987. He then studied for a PhD at Birkbeck College, University of London in the Department of Crystallography. Whilst there he was involved in developing automated approaches to protein modelling, contributing to the development of the software programmes COMPOSER and MODELLER, however his major research was on sequence-sturcture relationships, exploring the constraints applied by the local physical environment of a residue in it's mutation patterns (JOY and HOMSTRAD). After completing his PhD, John held a postdoctoral position at the Imperial Cancer Research Fund extending this research. John then joined Pfizer, originally as a computational chemist, progressing to a role where he led a multidisciplinary group combining rational drug design with structural biology. During this time, John became fascinated by the reasons for target/drug attrition and target validation, and the falling productivity of the entire pharmaceutical industry. John then moved to a small biotech company, where we developed a series of platforms to improve drug discovery, including the SAR database StARLite. In 2008 John was centrally involved in the transfer of this database to the EMBL-EBI, where the successor is known as ChEMBL,

Research Interest

Genomics Biochemistry Structural Biology Molecular Biology Data Mining Organic Chemistry Machine Learning Homology Modeling Molecular Dynamics Systems Biology