Journal of Microbial & Biochemical Technology

Jian-Bin Hu

Publications

• Research Article
  A Holistic In Silico Approach to Find Novel Inhibitors for Erbb1 and Erbb2 Kinases
  Author(s): Jian-Bin Hu, Ming-Jun Dong and Jun ZhangJian-Bin Hu, Ming-Jun Dong and Jun Zhang
  
  Lung cancer is the primary cause of cancer deaths worldwide. The two major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer, which account for 85% and 15% of all lung cancers, respectively. There are around 26 genes which are involved in most of the lung cancers, among which ErbB1 and ErbB2 are the most prominent. Combined chemotherapy is used to cure cancer, which increases the side-effects, and the drugs available also show severe adverse reactions. Thus, there is a dire need for the search of novel inhibitors with fewer side-effects. Molecules obtained from natural sources have fewer side-effects. Therefore, the current study focuses on finding a common inhibitor from available natural products and FDA approved drugs, which bind with both ErbB1 and ErbB2. A variety of approaches have been adopted in this study, including sequence and structure analysis,.. View More»
  DOI: 10.4172/1948-5948.1000278

  Abstract PDF