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Jenna-Lynn Senger
Jenna-Lynn Senger
Canada
Publications
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Review Article
Stromal Signatures of Breast Carcinogenesis in Fibroadenoma-A Pilot Study
Author(s): Rani Kanthan, Jenna-Lynn Senger and Kanthan SCRani Kanthan, Jenna-Lynn Senger and Kanthan SC
Background: Fibroadenoma (FA) is a benign breast neoplasm associated with an increased risk of subsequent carcinogenesis; yet, the relationship between these two events remains undetermined. Traditional breast paradigms that focus on the epithelial cell as the primary origin of cancer need to be revisited. Our working hypothesis is that, stromal dysfunction through epithelial-stromal ‘cross-talk’ in the host microenvironment is perhaps the earliest initiating event in breast carcinogenesis. Methods: 60 cases of randomly selected FA were analyzed in this study. Paraffin embedded tissue samples were analyzed using the antibodies TAG72, ErbB2, p53, CD10, Ki67, Bcl2, CD31, Nestin, and Laminin. Stromal and epithelial components were scored and compared on a semi-quantitative scale. Results: Six of the 60 cases subsequently developed bre.. View More»
DOI: 10.4172/2157-2518.1000123