Journal of Data Mining in Genomics & Proteomics

Javed N Agrewala

Biography

 Dr. Javed N Agrewala current research interest is in microbial pathogenesis in diseases like tuberculosis where a coordinated cross-talk between macrophages and T cells is essential for protection and wish to explore the following problems: (i) eventhough immunity is highly efficacious in preventing disease but is extraordinarily inefficient in terminating infection; (ii) why only 5-10% of the infected individuals develop active tuberculosis and the remaining 90% impart effective immunity against the M. tuberculosis; (iii) why macrophages play a “dual role” by providing protection to host as well as survival of the bacteria; (iv) what factors make the relationship between M. tuberculosis and host immunity labile, converting infection into clinical disease; (v) what are the regulatory signals delivered by the infected macrophages to effector T cells and in return what signals are transmitted by effector T cells to macrophages. This study would provide insights not only into mechanisms of pathogenesis but may also suggest targets for therapeutic intervention.

Research Interest

 Immunology (Vaccines and Immunomodulation)