Journal of Carcinogenesis & Mutagenesis

Jahn M. Nesland

Publications

• Research Article
  Intermediate Filament Proteins of Lamin A/C and Cytokeratin 18 are involved in Apoptotic Induction by Photodynamic Therapy with Hexaminolevulinate in Human Colon Carcinoma Cells
  Author(s): Susan Shahzidi, Mouldy Sioud, Andreas Brech, Sebastian Patzke, Jahn M. Nesland and Qian PengSusan Shahzidi, Mouldy Sioud, Andreas Brech, Sebastian Patzke, Jahn M. Nesland and Qian Peng
  
  Hexaminolevulinate (HAL), a hexylester of 5-aminolevulinic acid, is a precursor of the photosensitizer protoporphyrin IX (PpIX) and clinically used for photodynamic therapy (PDT) of cancer, an established modality with a light-activated drug. However, the mechanism involved in the killing cancer cells is still not fully understood. Our previous report (Cancer Lett., 2013; 339: 25-32) has shown a crucial role of caspase-6-mediated cleavage of lamin A/C, a member of type-V intermediate filaments (IFs), in the HAL-PDT-induced apoptosis in human B-cell lymphoma cells. Lamin A/C is present in all cell types; while cytokeratin 18, a major component of type-I IFs, is expressed only in the epithelial cells and carcinoma. This study has focused upon the roles of the two IF proteins, lamin A/C and cytokeratin 18 in the HAL-PDT-mediated apoptotic induction in the human colon carcinoma COLO 205 a.. View More»
  DOI: 10.4172/2157-2518.1000212

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