Journal of Carcinogenesis & Mutagenesis

Houchen CW

Publications

• Review Article
  Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells
  Author(s): Chandrakesan P, Panneerselvam J, Qu D, Weygant N, May R, Bronze MS and Houchen CWChandrakesan P, Panneerselvam J, Qu D, Weygant N, May R, Bronze MS and Houchen CW
  
  The identification of functionally relevant subpopulations of therapy-resistant cancer cells is a challenge. These cells, intrinsically resistant to conventional therapy, can cause recurrence. Evidence has suggested that therapyresistant cancer cells are likely epithelial–mesenchymal transition (EMT) cells and/or stem-like cells called cancer stem cells (CSCs). EMT, a normal embryological process that converts epithelial cells into mesenchymal cells, is frequently activated during cancer development and progression. CSCs are a small subpopulation of cancer cells within a tumor mass that have the ability to self-renew and maintain tumor-initiating capacity by giving rise to heterogeneous lineages of cancer cells that comprise the whole tumor. Although the origin of CSCs and EMT cells remains to be fully explored, a growing body of evidence has indicated that the biology of EMT an.. View More»
  DOI: 10.4172/2157-2518.1000257

  Abstract PDF