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Hit Kishore Goswami
Hit Kishore Goswami
Bhopal University,
24, Kaushalnagar, P.O. Misrod, Bhopal
India
Publications
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Research Article
Gross Chromosomal Aberrations are Early Alarms for Malignancy: A Re-Emphasis
Author(s): Hit Kishore GoswamiHit Kishore Goswami
A few chromatin dots of variable sizes were encountered in squashes of brain tumour tissues viz. medulloblastoma, ependymoma and tuberculoma along with hyper and hypoploid chromosome counts way back in 1973. Similar chromosomal features were again observed in metaphases of persons exposed to methylisocyanate gas in Bhopal during midnight of 2nd to 3rd December, 1984. Follow-up studies continued during 1984-1999 and comparative assessments on chromosomal damages were attempted by SCE (sister chromatid exchanges) as well as by scoring more than a dozen types of chromosomal aberrations on 678 individuals by C and G-banding and Feulgen’s and Aceto-orcein staining procedures on cultured-lymphocytes, details of which, have been published earlier. This short paper reemphasizes the importance of certain chromatin dots (named as Marker dots) which were seen emanating from chromosomes. Th.. View More»
DOI: 10.4172/2161-1041.1000187