Hisashi Matsushima

Hisashi Matsushima
Tokyo Metropolitan Police,
Hospital 4-22-1, Nakano, Nakano-Ku, Tokyo 164-0001

  • Research Article
    Androgen Deprivation Therapy Induces Vitamin K Loss in Men with Prostate Cancer
    Author(s): Hisashi MatsushimaHisashi Matsushima

    Bone strength is determined by bone mineral density (BMD) and bone quality. Bone fractures are serious adverse events in men receiving androgen deprivation therapy (ADT) for prostate cancer. Although it is established that ADT reduces BMD, it is unclear how ADT alters bone quality. Vitamin K is a bone quality marker which aids to carboxylates osteocalcin to form bone matrix. Serum undercarboxylated osteocalcin (ucOC) is accumulated in vitamin K deficiency, which is used as a surrogate for vitamin K status. As little is known as to the impact of ADT on serum ucOC, we investigated the changes of serum ucOC in PC patients during ADT. Fifty consecutive hormone naïve PC patients were enrolled. Serum ucOC, serum osteocalcin (OC), serum Nteloptide of type 1 collagen (NTx) and hip bone mineral density (BMD) were measured at baseline, 6 month and 12 months since the start of ADT. Serum uc.. View More»
    DOI: 10.4172/0974-8369.1000404

    Abstract PDF