Pharmaceutica Analytica Acta

Hiraoka H

Publications

• Research Article
  Effect of a Dietary Supplement Containing Raspberry Ketone on CYP3A Activity in Healthy Women
  Author(s): Aomori T, Qi JW, Okada Y, Nakamura K, Hiraoka H, Araki T, Nakamura T, Horiuchi R and Yamamoto KAomori T, Qi JW, Okada Y, Nakamura K, Hiraoka H, Araki T, Nakamura T, Horiuchi R and Yamamoto K
  
  Objective: Raspberry ketone (RK) is available as a supplement with effect on weight gain suppression. Recent studies have found that various herbal products can affect the activities of drug metabolizing enzymes and drug efflux proteins, and provoke clinically relevant drug-drug interactions. Capsaicin, a molecule having a similar chemical structure to RK, is another well-known cytochrome P450 (CYP) inhibitor. On the other hand, it is totally unclear whether RK has any effect on human CYP activities. In this study, we evaluated the effect of orally administered RK on CYP3A activity by measuring 6beta-hydroxycortisol/cortisol ratio in urine samples. Methods: This clinical study was conducted with approval by the Institutional Review Board at Gunma University Hospital. A total of 7 healthy women aged between 20 and 35 years were included and all .. View More»
  DOI: 10.4172/2153-2435.1000587

  Abstract PDF