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Hewala II
Hewala II
Egypt
Publications
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Research Article
Spectrofluorimetric Estimation of Some Sulfhydryl – Containing Drugs by Demasking Reaction of the Palladium Chelate of 8-Hydroxyquinoline-5-Sulfonic Acid
Author(s): Haggag RS, Belal SF, Hewala II and ElRouby OAHaggag RS, Belal SF, Hewala II and ElRouby OA
A simple and sensitive spectrofluorimetric method has been developed for the determination of some selected sulfhydryl–containing drugs namely Acetylcysteine (ACS), Captopril (CAP) and Mesna (MSN). The method is based on the interaction of the drugs with potassium (5-sulfoxino) palladium II in alkaline medium in presence of magnesium ions, where the sulfhydryl group combines with palladium from the non-fluorescent potassium bis (5-sulfoxino) palladium II. The resulting 8-hydroxy-5-quinoline sulfonic acid coordinates with magnesium to form the fluorescent chelate that is a measure of the amount of sulfhydrl containing drug analyzed. The fluorescence intensity was measured at an emission wavelength of 485 nm, by excitation at 345 nm. All the experimental parameters affecting the reaction were studied and optimized. The proposed method was applicable over the concentration range of.. View More»
DOI: 10.4172/2153-2435.1000532