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Haruo Sugi
Haruo Sugi
School of Medicine,
Tokyo
Japan
Publications
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Review Article
Evidence against the Swinging Lever Arm Mechanism in Muscle Contraction Based on the Effect of Antibodies to Myosin Head
Author(s): Haruo Sugi and Chaen S Haruo Sugi and Chaen S
During muscle contraction, myosin heads extending from myosin filaments first attach to actin filaments, perform power stroke producing force and motion in muscle, and then detach from actin filaments. A myosin head (or myosin subfragment-1, S-1) consists of catalytic and lever arm domains (CAD and LD), which are connected via converter domain (COD). It is widely believed that the myosin head power stroke is caused by swinging lever arm mechanism, which assumes active rotation of the LD around the COD, caused by structural changes in and around the COD. The lever arm mechanism is, however, constructed from nucleotide-dependent structural changes of crystals of truncated myosin head, consisting only of the CAD and the COD, and therefore overlooks possible role of the LD and myosin subfragment-2 (S-2), connecting myosin heads to myosin filament backbone.. View More»
DOI: 10.4172/2157-7439.1000377