Journal of Carcinogenesis & Mutagenesis

Griffiths Lyn R

Publications

• Research Article
  Fine Mapping of the 15q21 Region Implicates TP53BP1 and B2M in the Lymphomagenesis of Follicular and Diffuse Large B-Cell Lymphomas
  Author(s): Aya-Bonilla Carlos, Camilleri Emily, Benton Miles, Haupt Larisa M, Marlton Paula, Lea Rod A, Gandhi Maher K and Griffiths Lyn RAya-Bonilla Carlos, Camilleri Emily, Benton Miles, Haupt Larisa M, Marlton Paula, Lea Rod A, Gandhi Maher K and Griffiths Lyn R
  
  Background and aim: Recent studies focusing on the discovery of common alterations across cases suffering from follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) have reported loss of heterozygosity (LOH) and deletions events targeting the 15q21 region, indicating the relevance of this region in the lymphomagenesis of FL and DLBCL. Herein, we investigated the genetic structure of this region by studying identified LOH and copy-loss events and examined this region in the lymphomagenesis of FL and DLBCL. Methods: Fine mapping of the genomic region between the 15q15.1 and 15q21.1 loci was performed using data from copy number variation (CNV) and high resolution LOH analyses of FL (n=21) and DLBCL (n=21) cases. Validation of LOH of this region was performed using microsatellites followed by quantitative-PCR (qPCR) to measure the transcriptional abundance of TP53BP1 and B2M.. View More»
  DOI: 10.4172/2157-2518.1000195

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