Pharmaceutica Analytica Acta

Ghias Uddin

Publications

• Research Article
  Bioassay-guided Isolation of a Antinociceptive, Anti-inflammatory and Antipyretic Benzofuran Derivative from Viburnum grandiflorum
  Author(s): Ghias Uddin, Muhammad Alam, Naveed Muhammad, Bina S Siddiqui and Anwar SadatGhias Uddin, Muhammad Alam, Naveed Muhammad, Bina S Siddiqui and Anwar Sadat
  
  In tradition system of medicines the Vibernum grandiflorum is widely practiced as antipyretic in the treatment of malaria and typhoid. The current study was designed for scientific validation of antinociceptive, anti-inflammatory and antipyretic effect of V. grandiflorum with reference to its chemical composition. The crude ethanolic extract and isolated compound was tested for its antinociceptive effect using acetic acid and hot plate pain models. The anti-inflammatory potential was investigated through carrageenan induced oedema and antipyretic effect was determined using brewer?s yeast induced pyrexia. Beside the isolation of ?-sitosterol, ursolic acid and betulin, a benzofurane derivative, 2-(-4?-hydroxy-3?-methoxy-phenyl)-5-(3?-hydroxy-propyl)-3-hydroxy-methyl-7-hydroxy-2, 3-dihydrobenzofuran was first time isolated from the roots of V. grandiflorum. The crude extract and compound 1.. View More»
  DOI: 10.4172/2153-2435.1000274

  Abstract PDF