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Ghasem Ahangari
Ghasem Ahangari
Neuroimmuno Psycho Oncogenetic Group, Department of Medical Genetics, National Institfute of Genetic Engineering and,
Biotechnology, Tehran
West Indies
Publications
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Research Article
Significant Association between Catechol Amine O-Methyl Transferase (COMT) Gene Expression Changes and Breast Cancer Pathogenesis
Author(s): Ghasem Ahangari, Majid Pornour, Sayed Aminzadeh, Hossein Bakhtou and Hamid Reza AhmadkhanihaGhasem Ahangari, Majid Pornour, Sayed Aminzadeh, Hossein Bakhtou and Hamid Reza Ahmadkhaniha
Objective: The most prevalent cancer among Iranian women and worldwide is breast cancer. Catechol amine-o-methyltransfrase (COMT) methylates some neurotransmitters such as dopamine which is secreted in chronic stress conditions and controls the growth of cancer cells. This study was conducted to evaluate the role of alterations in the gene expression of COMT in peripheral blood mononuclear cells (PBMCs) and its specific enzyme activity in blood samples of breast cancer patients as a stress factors suppressor. Methods: Peripheral blood samples were obtained from 40 patients and 40 healthy individuals. Total mRNA was extracted from PBMCs and their plasma was stored to evaluate specific enzyme activity changes. RT-PCR was performed to confirm the presence of COMT gene expression in PBMCs. Expression changes of COMT gene were evaluated by real t.. View More»
DOI: 10.4172/2157-2518.1000219