Journal of Carcinogenesis & Mutagenesis

Gerardo Guillen-Nieto

Publications

• Review Article
  Epidermal Growth Factor (EGF) and Platelet-Derived Growth Factor (PDGF) as Tissue Healing Agents: Clarifying Concerns about their Possible Role in Malignant Transformation and Tumor Progression
  
  Author(s): Jorge Berlanga-Acosta, Jorge Gavilondo-Cowley, Diana García del Barco-Herrera, Jorge Martín-Machado and Gerardo Guillen-NietoJorge Berlanga-Acosta, Jorge Gavilondo-Cowley, Diana García del Barco-Herrera, Jorge Martín-Machado and Gerardo Guillen-Nieto
  
  EGF and PDGF, reminiscent of the early hopes of solution for problem wounds have attained a niche by healing diabetic ulcers. Although they belong to unrelated families, multiple biological features are shared. Mounting evidences reviewed here; document however, divergent and opposing roles for EGF and PDGF in both tissue repair and tumorigenesis. Wounds: As EGF receptor is not expressed by inflammatory cells, its ligand does not quantitatively or qualitatively modifies the course of inflammation. In contrast, PDGFB recruits and perpetuates inflammation. These infiltrated inflammatory cells turns and additional local source of growth factors. EGF enhances matrix synthesis via gene expression, while PDGF increases wound fibroblasts and myofibroblasts population density and exhibits far more chemotactic and angiogenic effect. Epithelialization is distinctly stimulated b.. View More»
  DOI: 10.4172/2157-2518.1000115

  Abstract