Journal of Carcinogenesis & Mutagenesis

Francis L. McCabe

Publications

• Research Article
  Tissue Factor (TF) Expression and Angiogenesis in Tumor Progression and Inhibition of Tumor Growth by Anti-TF Antibodies in Human Tissue Factor Knock-In Mice
  Author(s): Amy L. Volk, Laura Johns, Heena Beck, Francis L. McCabe, Patricia Rafferty, Devon D. Egenolf, Hillary Millar, Jin Lu, Barry Morse, Mark Anderson and Peter J. BugelskiAmy L. Volk, Laura Johns, Heena Beck, Francis L. McCabe, Patricia Rafferty, Devon D. Egenolf, Hillary Millar, Jin Lu, Barry Morse, Mark Anderson and Peter J. Bugelski
  
  Background: Tissue factor (TF) serves as the primary initiator of the extrinsic pathway of blood coagulation and mediates signaling via the protease activated receptor-2 (PAR2). TF is over-expressed in several tumor types and may facilitate tumor progression and angiogenesis. To test the hypothesis that inhibition of TF may have an anti-tumor effect, we induced pulmonary adenomas (PA) in human TF knock in (huTF-KI) mice with urethane and studied the relationship between expression of TF and mutations in K-ras with tumor progression and the effect of a monoclonal anti-TF antibody on growth of a transplantable lymphoma. Methods: huTF-KI mice received 10 weekly intraperitoneal (i.p.) injections of urethane and samples of lung were collected at six week intervals between weeks 10 and 28. Expression of TF and von Willibrand factor (vWF) in PA were studied by immunohistochemistry (IHC) and .. View More»
  DOI: 10.4172/2157-2518.S7-001

  Abstract PDF