Hereditary Genetics: Current Research

Elham Rastegarimoghaddam

Publications

• Research Article
  Expression Alteration of Disrupted in Schizophrenia 1 (DISC1) Gene, a Potential Peripheral Marker for Schizophrenia and Paranoid Personality Disorder
  Author(s): Jalal Rostampour1, Arvin Haghighatfard2,3*, Masoume Ghasemzadeh Qazvini4, Talie Karimi5, Elham Rastegarimoghaddam6, Atieh Alizadenik7 and Zahrasadat Hosseini8 Jalal Rostampour1, Arvin Haghighatfard2,3*, Masoume Ghasemzadeh Qazvini4, Talie Karimi5, Elham Rastegarimoghaddam6, Atieh Alizadenik7 and Zahrasadat Hosseini8
  
  Introduction: Schizophrenia (SCZ) is a major psychiatric disorder with unclear etiology or biological diagnosis. Paranoid Personality Disorder (PPD) is a type A personality disorder characterized by paranoia and generalized mistrust. Disrupted in schizophrenia 1 (DISC1) is a gene located on human chromosome 1 that is involved in neurodevelopment of brain. Variations and translocations in this gene were found associated with schizophrenia and other psychiatric disorders. Present study aimed to evaluate the expression alteration of DISC1 gene in peripheral blood of SCZ and PPD patients and its correlation with clinical features. Material and methods: Study was included 300 SCZ, 300 PPD and 300 non-psychiatric individuals. Total blood was collected and expression level of DISC1 evaluated by using quantitative Real time PCR SYBR green. Lymphocyt.. View More»
  DOI: 10.4172/2161-1041.1000188

  Abstract PDF