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Driver J
Driver J
Ireland
Publications
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Review Article
The Constituents and Potential Targets of the Extracellular Matrix:Implications for Carcinogenesis and Cancer Treatment
Author(s): Weber CE, Driver J, Franzen CA, Mascarenhas JB, Mi Z, Gupta GN, Wai PY and Kuo PCWeber CE, Driver J, Franzen CA, Mascarenhas JB, Mi Z, Gupta GN, Wai PY and Kuo PC
The dense extracellular matrix consists of a multitude of proteins with important implications in tumorogenesis that extend beyond the maintenance of tissue integrity. Several of the main macromolecular constituents- proteoglycans, collagens, integrins, and syndecans will be discussed in this review, with particular attention to their roles in tumor initiation, invasion, angiogenesis, and metastasis. In addition, a brief synopsis of the role of enzymes that remodel the extracellular matrix will be provided. Finally, specific examples of targeted molecular therapies: anti-integrin agents, MMP inhibitors, and hyaluronidase will be discussed. .. View More»
DOI: 10.4172/2157-2518.S13-006