Journal of Carcinogenesis & Mutagenesis

Chen Chen

Publications

• Research Article
  Antitumor Activity of Atractylenolide II on Breast Cancer Cells through Regulation of Estrogen Receptor Protein Expression and NF-Kb Signaling Pathways
  Author(s): Chao Yang, MI Nasser, Shuoji Zhu, Chen Chen, Salah Adlat, Muqaddas Masood, Zhu Ping and Nan JiangChao Yang, MI Nasser, Shuoji Zhu, Chen Chen, Salah Adlat, Muqaddas Masood, Zhu Ping and Nan Jiang
  
  Many women in the world are suffering from breast cancer deeply. Although many efforts are made in the study of breast cancer prevention and treatment, little attention is paid to the molecular mechanism of the disease. In the present study, considerable techniques such as western blotting, quantitative RT-PCR (qRT-PCR), Luciferase Immunohistochemistry, and flow cytometry analysis has been performed to analyze the effect of Atractylenolide II(ATR II) addiction for breast cancer research. As indicated by our research outcomes, ATR II could prohibit the proliferation of Prostate cancer as well as Breast cancer cells, in particular, ATR II induces MDA-MB231 and MCF-7 cells apoptosis, through G2/M -phase cell arrest. Also, cell apoptosis was induced by ATR II mainly associated with extrinsic mitochondrial pathways followed by activation of death receptor (DR4) that regulated activation of.. View More»
  

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