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Baojiang Chen
Baojiang Chen
Tanzania
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Research Article
Differences in MUC4 Expression in Pancreatic Cancers and Pancreatic Cysts in Egypt
Author(s): Asserewou Etekpo, Ahmad Alghawalby, Marwa Alghawalby, Amr S Soliman, Ahmed Hablas, Baojiang Chen, Surinder Batra and Ghada A SolimanAsserewou Etekpo, Ahmad Alghawalby, Marwa Alghawalby, Amr S Soliman, Ahmed Hablas, Baojiang Chen, Surinder Batra and Ghada A Soliman
Pancreatic cancer is the fourth cause of cancer deaths in the U.S. with most patients diagnosed at advanced stages followed by short survival. Therefore, biomarkers for early detection are urgently needed. Mucin 4 (MUC4) is a mucin protein encoded by the MUC4 gene and identified in the majority of pancreatic cancers. With increasing clinical identification and diagnosis of pancreatic cysts globally and transformation of some cysts into pancreatic cancer, it is important to evaluate if MUC4 is expressed in pancreatic cysts. Immunohistochemistry assays utilizing heat-induced epitope retrieval (HIER) were performed to examine MUC4 protein expression in 44 paraffin-embedded tissues of pancreatic cancers and 20 pancreatic cysts. All patients were diagnosed and operated upon at the Mansoura University Gastrointestinal Surgery Center in Egypt. Clini.. View More»
DOI: 10.4172/2157-2518.1000312