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Alla Yugay
Alla Yugay
Russian Federation
Publications
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Research Article
Cytochrome 2C19 Enzyme Polymorphism Frequency in Different Indigenous Ethnic Groups in Russian Federation: A Systematic Review
Author(s): Karin Mirzaev, Dmitriy Sychev, Goar Arutyunyan, Alla Yugay and Denis AndreevKarin Mirzaev, Dmitriy Sychev, Goar Arutyunyan, Alla Yugay and Denis Andreev
Background and objective: Genetically determined diversity in the activity of cytochrome P450 (CYP) – enzyme regulating the biotransformation of drugs and xenobiotics – is one of the main causes of interindividual differences in response to pharmacotherapy. The objective of this review is to analyze the prevalence of polymorphic markers of gene CYP2C19, associated with the violation of the pharmacological response to clopidogrel among the various ethnic groups living in the Russian Federation. Methods: A literature review was conducted using the following databases: MEDLINE and eLIBRARY.RU. Russian language articles published between 20032003 (the first publication in Russians) and 2014 were reviewed. Results: The authors detected 11 original research studies on CYP2C19 gene in 11 indigenous ethnic groups o.. View More»
DOI: 10.4172/2153-0645.1000136